Formulation and Evaluation of Physical Properties of Antioxidant Effervescent Granules and Extract of Karamunting Flower (Melastoma malabathricum L.)

Shesanthi Citrariana; Yahya Febrianto; Thathit Suprayogi; Emma Ayudia Noriadita

doi:10.58330/inovasia.v2i2.359

Authors

Shesanthi Citrariana Universitas Palangka Raya
Yahya Febrianto Universitas Palangka Raya
Thathit Suprayogi Universitas Palangka Raya
Emma Ayudia Noriadita Universitas Muhammadiyah Palangkaraya

DOI:

https://doi.org/10.58330/inovasia.v2i2.359

Keywords:

Antioxidants, Effervescent Granules, Karamunting Flower, Physical Properties

Abstract

Karamunting (Melastoma malabathricum L.) contains several compounds with pharmacological activities including antioxidant, analgesic, anti-inflammatory, antipyretic and diuretic. Karamunting flowers contain flavonoid compounds, saponins and tannins. Tannin compounds can stabilize free radicals by complementing the electron deficiency of free radicals. To increase the utilization of karamunting flowers, it is formulated in the form of effervescent granules. This study aims to determine the ethanol extract of karamunting flower (Melastoma malabathricum L.) with concentrations of 1%, 2%, and 3% can be formulated in the form of effervescent granules. The physical properties of the granules were tested which included organoleptic test, flow rate test, granule compressibility test, dissolving time test and pH of effervescent granules. The results showed that formula 3 with a concentration ratio of 3% ethanol extract was a formula that met the requirements for the physical properties of the granules, namely with a sweet and sour taste, a characteristic odor of karamunting, and a dark purple-brown color. With an average flow rate of 2.853 g/sec, average compressibility of 21.12%, an average dissolving time of 7.52 seconds and a pH measurement of 5.

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References

Adi-Dako, O., Kumadoh, D., Egbi, G., Okyem, S., Addo, P. Y., Nyarko, A., Osei-Asare, C., Oppong, E. E., & Adase, E. (2021). Strategies for formulation of effervescent granules of an herbal product for the management of typhoid fever. Heliyon, 7(10), e08147. https://doi.org/10.1016/j.heliyon.2021.e08147

Arief, M. I., Novriansyah, R., Budianto, I. T., & Bimo, M. (2012). Potensi Bunga Karamunting (melastoma Malabathricum L.) Terhadap Kadar Kolesterol Total Dan Trigliserida Pada Tikus Putih Jantan Hiperlipidemia Yang Diinduksi Propiltiourasil. 1.

Daswi, D. R. (2021). Formulation And Physical Quality Of Effervescent Granules Containing Rambutan (Nephelium lappaceum L) Peel Dried Extract. 1.

Grajang, I. B., & Wahyuningsih, I. (2018). Formulation of Sechium edule Extract Effervescent Granule with the Variation of Citric Acid, Tartrate Acid and Sodium Bicarbonate: Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development, 54–60. https://doi.org/10.5220/0008239300540060

Gupta, R., Sharma, P., Garg, A., Soni, A., Sahu, A., Rai, S., Rai, S., & Shukla, A. (2013). Formulation and Evaluation of Herbal Effervescent Granules Incorporated with Calliandra Haematocephala Leaves Extract. Indo American Journal of Pharmaceutical Research, 3(6).

Gustaman, F., Idacahyati, K., & Wulandari, W. T. (2021). Formulation and evaluation of Kirinyuh Leaf effervescent granules (Chromolaena Odorata. L) as an antioxidant. Pharmacy Education, 21(2), 123–125. https://doi.org/10.46542/pe.2021.212.123125

Isnaini, I., Yasmina, A., & Nur’amin, H. W. (2019). Antioxidant and Cytotoxicity Activities of Karamunting (Melastoma malabathricum L.) Fruit Ethanolic Extract and Quercetin. Asian Pacific Journal of Cancer Prevention, 20(2), 639–643. https://doi.org/10.31557/APJCP.2019.20.2.639

Jayasuriya, W. J. A. B. N., Hettiarachchi, H. U. V., Kumara, T. D. M. T. S., Dias, N. T. B., Arawwawala, L. D. A. M., & Suresh, T. S. (2022). Formulation and evaluation of in vitro antacid effect of effervescent granules containing extracts of Evolvulus alsinoides. Pharmaceutical Journal of Sri Lanka, 12(1), 9–19. https://doi.org/10.4038/pjsl.v12i1.84

Joffry, S. Mohd., Yob, N. J., Rofiee, M. S., Affandi, M. M. R. M. Mohd., Suhaili, Z., Othman, F., Akim, A. Md., Desa, M. N. M., & Zakaria, Z. A. (2012). Uji Aktivitas Antioksidan, Penetapan Kadar Fenolik dan Flavonoid Total Ekstrak Etanol dari Daun, Batang, dan Kulit Batang Karamunting (Melastoma malabathricum L.). Evidence-Based Complementary and Alternative Medicine, 2012, 1–48. https://doi.org/10.1155/2012/258434

Mahdiyyah, M., Puspitasari, I. M., Putriana, N. A., & Syamsunarno, M. R. A. A. (2020). Review: Formulasi dan Evaluasi Sediaan Oral Effervescent. Majalah Farmasetika, 5(4). https://doi.org/10.24198/mfarmasetika.v5i4.27278

Niah, R., & Baharsyah, R. N. (2018). Potensi Ekstrak Daun Tanaman Karamunting (melastoma Malabathricum L.) Di Daerah Kalimantan Sebagai Antibakteri Staphylococcus Aureus. Jurnal Ilmiah Manuntung, 4(1), 36–40. https://doi.org/10.51352/jim.v4i1.138

Pertama, N. M. S., Kusuma, I. W., Amirta, R., & Fitriah, N. I. (2021). TUMBUHAN KARAMUNTING (Melastoma malabathricum).

Syamsul, E. S. (2014). Formulation of Effervescent Powder of Water Extract of Bawang Tiwai (eleuterine Palmifolia) as a Healthy Drink.

Utama, M. D., Chotimah, C., Achmad, H., Arifin, N. F., & Furqani, A. W. (2021). Effect of Solvent Temperature in Effervescent Granule Denture Cleanser with Cacao Pod (Theobroma cacao l) 6,5% toward The Growth of Streptococcus mutans and Candidaalbicans. 25(4).

Vediya, P., Vaghasiya, D., & Mehta, D. (2022). Herbal Based Effervescent Granules of Giloy Sattva. 10(12).